pI: 6.5874 |
Length (AA): 374 |
MW (Da): 41675 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
41 | 356 | 2ymu (A) | 8 | 338 | 27.00 | 0 | 1 | 0.87272 | 0.64 |
48 | 230 | 3uvk (A) | 44 | 203 | 27.00 | 0.000025 | 1 | 0.764105 | -0.53 |
50 | 350 | 3bg1 (A) | 14 | 291 | 46.00 | 0 | 1 | 1.18161 | 0.05 |
329 | 360 | 4ery (A) | 95 | 126 | 22.00 | 0.0042 | 0.53 | 0.290462 | 0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127687)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G01340 | transport protein SEC13B |
Arabidopsis thaliana | AT2G30050 | transport protein SEC13A |
Brugia malayi | Bm1_36835 | SEC13-related protein |
Candida albicans | CaO19.7948 | WD domain protein similar to S. cerevisiae SEC13 (YLR208W) secretory pathway vesicle COPII coat component |
Candida albicans | CaO19.316 | WD domain protein similar to S. cerevisiae SEC13 (YLR208W) secretory pathway vesicle COPII coat component |
Caenorhabditis elegans | CELE_Y77E11A.13 | Protein NPP-20, isoform B |
Cryptosporidium hominis | Chro.80472 | hypothetical protein |
Cryptosporidium parvum | cgd8_4110 | hypothetical protein |
Dictyostelium discoideum | DDB_G0292052 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG6773 | Sec13 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000149000 | sec13 protein |
Entamoeba histolytica | EHI_001050 | sec 13 protein, putative |
Echinococcus multilocularis | EmuJ_000149000 | sec13 protein |
Giardia lamblia | GL50803_137698 | Sec13 |
Homo sapiens | ENSG00000157020 | SEC13 homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.32.0100 | protein transport protein Sec13, putative |
Leishmania donovani | LdBPK_320050.1 | protein transport protein SEC13 |
Leishmania infantum | LinJ.32.0050 | protein transport protein Sec13, putative |
Leishmania major | LmjF.32.0050 | protein transport protein Sec13, putative |
Leishmania mexicana | LmxM.31.0050 | protein transport protein Sec13, putative |
Loa Loa (eye worm) | LOAG_01167 | Sec13l1-prov protein |
Mus musculus | ENSMUSG00000030298 | SEC13 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_023040 | hypothetical protein |
Oryza sativa | 4334673 | Os03g0831800 |
Oryza sativa | 4342827 | Os07g0246300 |
Oryza sativa | 4328228 | Os02g0135800 |
Plasmodium berghei | PBANKA_1445400 | protein transport protein SEC13, putative |
Plasmodium falciparum | PF3D7_1230700 | protein transport protein SEC13 |
Plasmodium knowlesi | PKNH_1450100 | protein transport protein SEC13, putative |
Plasmodium vivax | PVX_124175 | protein transport protein SEC13, putative |
Plasmodium yoelii | PY01574 | hypothetical protein |
Plasmodium yoelii | PY03775 | hypothetical protein |
Saccharomyces cerevisiae | YLR208W | GTPase-activating protein SEC13 |
Schistosoma japonicum | Sjp_0010270 | ko:K08171 MFS transporter, OPA family, solute carrier family 37, putative |
Schistosoma japonicum | Sjp_0302910 | Protein SEC13 homolog, putative |
Schistosoma mansoni | Smp_090870 | protein transport protein Sec13 |
Schmidtea mediterranea | mk4.007775.04 | Protein SEC13 homolog |
Schmidtea mediterranea | mk4.002474.03 | Protein SEC13 homolog |
Trypanosoma brucei gambiense | Tbg972.10.16570 | protein transport protein Sec13, putative |
Trypanosoma brucei | Tb927.10.14180 | protein transport protein SEC13 |
Trypanosoma congolense | TcIL3000_10_12050 | protein transport protein SEC13 |
Trypanosoma cruzi | TcCLB.506525.20 | protein transport protein SEC13 |
Trypanosoma cruzi | TcCLB.511283.20 | protein transport protein SEC13 |
Toxoplasma gondii | TGME49_201700 | WD domain, G-beta repeat-containing protein |
Toxoplasma gondii | TGME49_201690 | BT1 family protein |
Trichomonas vaginalis | TVAG_456890 | protein transport protein sec13, putative |
Trichomonas vaginalis | TVAG_158010 | protein transport protein SEC13, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14180 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14180 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14180 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14180 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y77E11A.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y77E11A.13 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y77E11A.13 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y77E11A.13 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y77E11A.13 | Caenorhabditis elegans | sterile | wormbase |
YLR208W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1445400 | Plasmodium berghei | Essential | plasmo |
TGME49_201690 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_201700 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_201690 | Toxoplasma gondii | Probably essential | sidik |
TGME49_201700 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.